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Varenicline Stop Smoking Pill
A Pfizer drug shown to help more than one in five smokers stop smoking received federal approval on Thursday, adding another option to the limited pool of effective stop-smoking prescription medicines.
The drug also slows the release of dopamine, which cuts the craving to smoke that occurs when nicotine's effect wears off, said Pfizer research chemist Jotham Coe, who invented the drug.
Varenicline works in two ways, by cutting the pleasure of smoking and reducing the withdrawal symptoms that lead smokers to light up cigaret again. Most other stop-smoking pills are various nicotine-replacement therapies, sold by prescription and over the counter in gum, patch, lozenge, nasal spray or inhaler form. In 1997, the FDA approved bupropion, an antidepressant already sold as Wellbutrin but rebranded it as Zyban, an anti-smoking drug. Perfection has been achieved in this article on overcoming cigarette addiction. There is hardly any matter left from this article that is worth mentioning.Perfection has been achieved in this article on overcoming cigarette addiction. There is hardly any matter left from this article that is worth mentioning.
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"It's a shield and at the same time, it stabilizes you and prevents you from having the lows, which lead to craving and withdrawal, but at the same time, it shields you from the highs," said Coe, a former 2 1/2 pack-a-day smoker who quit smoking a first time cold turkey and then a second time with the help of nicotine gum.
"It's not going to be a revolution, it's going to be a substantial step forward," Thomas Glynn, director of cancer science and trends at the American Cancer Society, said of varenicline. Glynn added that the greatest value will be for smokers who have tried Zyban or nicotine-replacement therapy but failed to quit. If there is the slightest possibility of you not getting to understand the matter that is written here on overcoming cigarette addiction, we have some advice to be given. Use a dictionary!
"Tobacco use, particularly cigarette smoking, is the single most preventable cause of death in the United States and is responsible for a growing list of cancers, as well as chronic diseases including those of the lung and heart," said Dr. Scott Gottlieb, the FDA's Deputy Commissioner for Medical and Scientific Affairs.
Both the FDA and European regulators recently shot down attempts by Sanofi-Aventis to gain approval for rimonabant, or Accomplia, as a stop-smoking aid. Both have recommended that the drug, which blocks the same pleasure centers in the body activated when pot smokers get the munchies, be approved for weight loss.
The approved course of Chantix pill treatment is 12 weeks, a period that can be doubled in patients who successfully stop to increase the likelihood they will remain smoke-free, the Food and Drug Administration said. This article serves as a representative for the meaning of overcoming cigarette addiction in the library of knowledge. Let it represent knowledge well.
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Quitting, as any smoker will tell you, isn't easy. Fewer than one in 20 smokers can do so without help, Schroeder said. With help, whether it's a drug, counseling or both, the success rate rises at most to roughly one in five, he added.
"My bet is that it will work as well as they do and, from the look of things, a little bit better," he said. Varenicline latches on to the same receptors in the brain that nicotine binds to when inhaled in cigarette smoke, an action that leads to the release of dopamine in the pleasure centers of the brain. Taking the drug blocks any inhaled nicotine from reinforcing that effect.
One in five American adults, or nearly 45 million people, smoke. An estimated 32 million of those smokers would like to quit, according to the Centers for Disease Control and Prevention. Smoking kills nearly 440,000 Americans a year.
Other clinical trials show the drug's effect is more pronounced in the short-term: 44 percent of patients quit smoking following a 12-week course of treatment with Chantix, compared to the 30 percent of Zyban patients who quit, according to Pfizer. However, smoking cessation experts said the longer-term data are more applicable, given the difficulty of quitting the habit for good.
Varenicline is only the second nicotine-free smoking cessation drug to gain FDA approval. Pfizer Inc. plans to market the twice-daily tablet as Chantix stop smoking pill.
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